Informatics Publishing Limited

Jairaj K. Dawle ¹, V. B. Suryawanshi ², S. R. Mathapati ³, A. S. Bondge ⁴, K. I. Momin ⁵

Affiliations
1 Reserch Lab of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga, Dist: Latur, IN
2 Department of Chemistry, K M C College, Khopoli, Dist Raigad, IN
3 Department of Chemistry, S. M. P. College, Murum, Omerga, Dist: Osmanabad, IN
4 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur, Anantpal, Dist Latur, IN
5 Department of Chemistry, Rajshri Shahu Mahavidhyalaya, Latur, IN

Abstract

Numerous imidazole derivatives are reported as pharmacological agents like azomycin, clotrimazole, Miconazole, ergothionine, clonidine and moxonidine. One of the most important applications of imidazoles derivatives are treatment for denture and cancer therapy. Imidazoles are in general, well known to possess, anti-cancer activity. These compounds are 5 membered planar ring, soluble in water and other polar solvents. Radziszewski and Jaapproposed the first synthesis of the imidazole corein 1882, starting from 1,2-dicarbonyl compounds, aldehydes and ammonia to obtain 2,4,5-triphenylimidazole [1, 2].

Keywords

Imidazole, Zinc Sulphate, Trisubstitution etc.

Full Text

     

Jairaj K. Dawle ¹, K. I. Momin ², S. R. Mathapati ³, A. S. Bondge ⁴, V. B. Suryawanshi ²

Affiliations
1 Department of Chemistry, Rajshri Shahu Mahavidhyalaya, Latur, IN
2 Department of Chemistry, K M C College, Khopoli, Dist Raigad, IN
3 Department of Chemistry, S. M. P. College, Murum, Omerga, Dist: Osmanabad, IN
4 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur, Anantpal Dist Latur, IN

Abstract

The objective of present research work is to provide green technique for synthesis of 2,3-diphenyl quinoxaline. Quinoxaline derivatives are well known in the pharmaceutical industry. A simple, highly efficient and green procedure for the condensation of α-phenylenediamine with α-diketones in the presence of catalytic quantity of iodine. Thevery mild reaction conditions, the high yields of the products, and the use of water as solvent make this methodology an efficient and green route for synthesis of quinoxalines derivatives.

Keywords

Diamine, Diketones, Quinoxaline, Iodine Catalyst, Water, Green Method.

Full Text